IFNB1 抗体
Quick Overview for IFNB1 抗体 (ABIN2665499)
抗原
See all IFNB1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
纯化方法
- The antibody was purified by antigen-affinity chromatography.
-
亚型
- Ig Fraction
-
-
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 22-187) antibody
IFNB1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 101-187) antibodyIFNB1 适用: 人, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) antibodyIFNB1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C13 unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 39-66) antibodyIFNB1 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 39-66), (N-Term) antibodyIFNB1 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB22040 unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 23-169) antibodyIFNB1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 23-169) antibodyIFNB1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 22-187) antibodyIFNB1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 1-187) antibodyIFNB1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 101-184) antibodyIFNB1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
-
-
- IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))
-
别名
- IFN-beta
-
背景
- Interferon-β is a member of the type I interferon class. Type I IFNs are involved in the innate immune system, being released non-specifically during the early stage of infection in response to stimuli such as viruses, dsRNA, LPS, and bacterial components. Once secreted by virus-infected or activated cells, they bind to the IFNα/β receptor (IFNAR), which is found on almost all cell types, and, via the JAK-STAT pathway, induce the expression of hundreds of IFN-stimulated genes (ISGs). While the function of many of these proteins remains to be elucidated, a hallmark of type I IFNs is their anti-viral activities, both general and specific against particular viruses. Type I IFNs also regulate cell growth and apoptosis, and exert various immunomodulatory and inflammatory effects. As such, they are also clinically relevant, both as therapeutics and as targets of inhibition for the treatment of various autoimmune diseases and cancer. Mouse IFN-β is a ~20 kD monomeric glycoprotein. It has 50 % amino acid sequence homology with mouse IFN-α, its closest related protein, and 62 % homology with human IFN-β. IFN-β is currently the therapeutic of choice for treating multiple sclerosis.
-
途径
- JAK/STAT Signaling, TCR Signaling, TLR signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Autophagy, Inflammasome
抗原
-
